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KMID : 0043320080310121547
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Archives of Pharmacal Research
2008 Volume.31 No. 12 p.1547 ~ p.1551
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Cytotoxic Macrocyclic Diterpenoids from Euphorbia helioscopia
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Zhu Wei-Ming
Liu Pei Pei
Hao Xiao-Jiang
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Abstract
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A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC50 values of 2.7 and 9.0 μM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
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KEYWORD
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Diterpenoid, Euphornin L, X-ray, Euphorbia helioscopia L, Cytotoxicity
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